I'm assuming you are asking if you can buy school textbooks at any bookstore. It really depends on where you go to school and what is required in that class. The biggest book store that the US has anymore, AFAIK, is Barnes and Noble. They should have most books you will need.
Also, the town you will be in might have some smaller bookstores. Usually the colleges have bookstores on campus as well. When I was in college I bought most of my books online(since you can find better deals there).
If you do not mind me asking, what part of the US will you be visiting/attending college?